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Hi.

This cactus has a american quarter sized black spot.

Is it possible to cure or should I cut the spot.

It is a one metre tall cereus peruvianus monstruosa.

Any help will be appreciated.

It is a consequence of stress. Probably caused by high temperatures. I have noticed this on several of my Trichoseurusa pachanoi. Watch the video from Desert plant of Avalon: https://www.youtube.com/watch?v=deCzO0q9aNg
Unfortunately, there will be a hole left when the cactus heals.

Thanks for the response and link.